For me it’s Fusion 360. The launcher for it opens your browser to log you in via the Web. Wine doesn’t seem to support that.
DCS has some sort of time/zone issue preventing me from logging in.
My MX Master scroll wheel behaves oddly.
Other than that it’s been not awful since I switched to Linux last month.
Man, I hate that BlueTooth doesn’t have an equivalent of “line-out” that isn’t affected by the host devices’ volume settings. It’s so annoying when I can barely hear my music because I turned the volume way down on my phone while watching a video late last night.